One type of inflammation and pain that happens in the foot is metatarsalgia, which originates in the metatarsal or ball of the foot (typically at the heads where the ball meets the three middle toes). It is also called stone bruise and is a common problem for metatarsal joints and bones. It commonly occurs behind the big toe at the ball of the foot. People who are physical active, such as runners, often get this condition. It can result from footwear that fits poorly or some other medical problem.
Causes. The two nerves that run between the metatarsals can be affected when the head of one of the bones presses against the other bone. The nerve becomes inflamed, leading to metatarsalgia. When weight is applied to the foot, the condition worsens because the bones rub together more. This inflames the nerve even more.